Institute for experimental Immunology (IEI), University Hospital Bonn



Interplay of innate lymphoid cells and regulatory T cells in inflammasome dependent nephritis

Inflammasome-induced nephritis is mainly triggered by activated dendritic cells and macrophages via the production of pro-inflammatory cytokines such as IL-1b, TNF, IL-6 and IL-18. ILCs seem to promote an inflamed environment by enhancing the inflammatory process and by interacting with CD4+ T helper cells. In this project we investigate the interplay of CD4+ T cells and ILCs in NLRP3-inflammasome-induced kidney inflammation. Furthermore, we will specifically focus on the role of NLRP3-inflammasome-induced cytokines on the activation and plasticity of the renal ILC populations.


Dr. Isis Ludwig-Portugall
Project Leader
Teresa Frasconi
PhD student







A NLRP3-specific inflammasome inhibitor potently attenuates crystal-induced kidney fibrosis in vivo. Isis Ludwig-Portugall*, Eva Bartok*, Ermanila Dhana, Beatrix D.G. Evers, Michael J. Primiano, J. Perry Hall, Bernardo S. Franklin, Veit Hornung, Gunther Hartmann, Peter Boor, Eicke Latz, Christian Kurts. Kidney Int. 2016 *joint first autorship