Institute for experimental Immunology (IEI), University Hospital Bonn
Interplay of innate lymphoid cells and regulatory T cells in inflammasome dependent nephritis
Inflammasome-induced nephritis is mainly triggered by activated dendritic cells and macrophages via the production of pro-inflammatory cytokines such as IL-1b, TNF, IL-6 and IL-18. ILCs seem to promote an inflamed environment by enhancing the inflammatory process and by interacting with CD4+ T helper cells. In this project we investigate the interplay of CD4+ T cells and ILCs in NLRP3-inflammasome-induced kidney inflammation. Furthermore, we will specifically focus on the role of NLRP3-inflammasome-induced cytokines on the activation and plasticity of the renal ILC populations.